第7回講演会 発表要旨

Lecture 1:

Thinking of Neurodegeneration as a Systems Failure

Peter Wellstead
(Professor (Emeritus) National University of Ireland, Maynooth and Manchester University, UK.)

　 An introductory discussion on why a new way of understanding neurodegeneration is essential help for our aging societies. Parkinson’s disease as a prototype neurodegenerative condition. Parkinson’s disease as a multifactorial systems failure with multiple risk and vulnerability factors. The similarity between age-related systems failures in machines and neurodegeneration. The need to understand the pre-failure period for effective disease prevention. An energy systems theory with brain energy metabolism failure as a unifying theme for all forms of Parkinson’s. A mathematical model of brain energy metabolism (BEM) as a framework for systems analysis of Parkinsonian risk factors. An evolved feedforward brain energy control structure and its implication for Parkinson’s disease vulnerability due to head trauma.

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